Material safety data sheet acetonitrile msds section 1. In a wellconducted study in mice, the oral ld50 of acetonitrile was calculated to be 617 mgkg. It is also a hazardous chemical substance and regulated as such throughout most of. Chemical product and company identification product name. Incompatible materials strong oxidizing agents, strong acids, reducing agents, bases hazardous decomposition productshydrogen cyanide hydrocyanic. Further, acetonitrile can also be used as the solvent in the process of producing synthetic fiber and special paints. Seastar chemicals inc msds perchloric acid page 3 of 5 personal protective equipment eyes. Acetonitrile 75058 100 toxicological data on ingredients. Common name acetonitrile english name acetonitrile cas number 75058 molecular weight 41. Other information revision b, june 2015 the information contained herein is provided in good faith and is believed to be correct as of the date hereof.
Acetonitrile safety data sheet according to federal register vol. Occupational exposure limits, if available, are listed in section 8. Consider cyanide antidote as clinically indicated, such as sodium thiosulfate and sodium nitrate. Produced mainly as a byproduct of manufacturing acrylonitrile, acetonitrile is a colorless liquid with an etherlike odor. Acetonitrile acn is also known as cyanomethane or methyl cyanide. The handling of this chemical may incur notable safety precautions. Acetonitrile is a toxic, colorless liquid with an etherlike odor and a sweet, burnt taste. Material safety data sheet acetonitrile section 1 chemical product and company identification msds name. India veritas house, 70 mint road, fort, mumbai 400 001. It is also a hazardous chemical substance and regulated as such throughout most of the world. Acetone safety data sheet according to federal register vol.
Incompatible materials strong oxidizing agents, strong acids, reducing agents, bases hazardous decomposition productshydrogen cyanide hydrocyanic acid, nitrogen oxides nox. Acetonitrile, also known as methyl cyanide or cyanomethane is a colorless chemical compound in liquid form having chemical formula ch 3 cn. Firstaid measures eyes rinse with plenty of water for at least 15 minutes and seek medical attention immediately. Acetonitrile, an aliphatic nitrile, is widely used as an organic solvent and intermediate in organic syntheses. Hazards identification classification of the substance or mixture signal word. P271 use only outdoors or in a wellventilated area. First aid measures eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Relevant identified uses of the substance or mixture and uses advised against. Safety data sheet according to federal register vol. Registration number 75 05 8 200 835 2 608 001 00 3 01 2119477 38 xxxx 4. Acetonitrile is metabolized in the liver to water, formic acid, and hydrogen cyanide.
In industry, it is likewise used as a solvent for the manufacture of such products as pharmaceuticals. Acetonitrile decomposes when heated to produce deadly toxic hydrogen cyanide gas and oxides of. Acetonitrile ch 3 cn, cas 75058, also known as methyl cyanide or cyanomethane, is the simplest organic nitrile. P280 wear eye protection, face protection, protective clothing, protective gloves. Acetonitrile revision date 17january2018 protective gear. Firstaid measures inhalation remove victim to fresh air and keep at rest in a position comfortable for breathing. For extraction in fat and oil processing, fatty acids can. Adg acetonitrile solution ab sciex australia pty ltd po box 514. May be harmful if swallowed, inhaled, or absorbed through the skin. Keep away from open flames, hot surfaces and sources of ignition. Fire hazard, acute health hazard, chronic health hazard 16. Here you will find all you need for administrative compliance to support your use of romil products.
First aid measures general advice consult a physician. It is used as a polar aprotic solvent in organic synthesis and in the purification of butadiene. Accidental release measures personal precautions remove all sources of ignition. This reagent is intended for nterminal protein sequencing applications. Acetonitrile revision date 17january2018 stability stable under normal conditions. Acetonitrile is a clear, colorless liquid with a sweet, ethereal odor. Three volunteers were exposed for 4 hours at 40, 80, or 160 ppm acetonitrile. Documentation is provided as pdf files and you must be logged in to your myromil account in order to download if a particular document is not currently available in our online library your request will be automatically forwarded to us and will receive our prompt attention. Industrially, it is used as a solvent in the purification of butadiene and in the manufacturing of photographic film. Thermal decomposition can lead to release of irritating gases and vapors. Calculate concentration, c, of acetonitrile in the air volume. Ace acetic acid nitrile cyanomethane ethane nitrile ethyl nitrile methane carbonitrile methyl cyanide. Wear appropriate protective face shield and eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910.
It is highly recommend that you seek the material safety datasheet for this chemical. If w b w f10, report breakthrough and possible sample loss. Acetonitrile hplc, fisher chemical fisher scientific. At 40 ppm, odor was detected, after which olfactory fatigue was noted. Acetonitrile market global industry analysis, size and. Skin contact wash off immediately with plenty of water for at least 15 minutes. Wear appropriate protective neoprene or polyethylene gloves to prevent skin exposure. Advancebio peptide chromatography columns with acetonitrile and water less than 10ml section 2. Toxicity data oral rat 2,460 mgkg ld50 oral mouse 591 mgkg ld50 8 h inhalation rat,740 ppm lc50 4 h inhalation mouse 3,587 ppm lc50 skin rabbit 2,000 mgkg ld50 oral rat 2460 mgkg ld50 inhalation rat. Safety data sheet sds acetonitrile, 15% solution 01.
Hazards identification potential acute health effects. This page provides supplementary chemical data on acetonitrile. Treatment and disposal methods for waste chemicals irptc file. It is transparent to uvvisible light, which makes it highly applicable in spectrophotometric and fluorimetric techniques. Inhalation move casualty to fresh air and keep at rest. Mecn is utilized as a mobile phase component in many chromatographic techniques.
Acetonitrile is produced primarily as an acrylonitrile manufacture byproduct. Some relevant physical and chemical properties of acn are listed below who, 1993. Sigmaaldrich material safety data sheet product name. Identification product identifier acetonitrile, distilled in glass other means of identification product code 1233 cas number 75058 synonyms ethane nitrile methyl cyanide cyanomethane professional, scientific and technical activities. Identification of the substancemixture and of the companyundertaking 1. If inhaled if breathed in, move person into fresh air. Upload files that contain viruses, corrupted files, or any other similar software or. Material safety data sheet for acetonitrile, product number. Acetonitrile cas no 75058 material safety data sheet.
Cyanobearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst. Show this safety data sheet to the doctor in attendance. It is produced mainly as a byproduct of acrylonitrile manufacture. Upload files that contain software or other material protected by intellectual property laws or by rights of privacy of publicity unless you own or control the rights thereto or have received all necessary consents. Acetonitrile in water 20%, s4b thermo fisher scientific. It is an extremely dangerous substance and must be handled with caution as it can cause severe health effects andor death. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone. Hazards identification medical conditions aggravated by overexposure preexisting disorders involving any target organs mentioned in this msds as being at risk may be aggravated by overexposure to this product no known significant effects or critical hazards. Acetonitrile is on the right to know hazardous substance. Acetonitrile is the chemical compound with the formula ch 3 cn. H373 may cause damage to organs through prolonged or repeated. More sds files for chemicals 75047 7504941 75051557 75056972 7505714 750590182 75059222 75062543 75070 75073119.
Take precautionary measures against static discharges. Acetonitrile by dupont dated 032802 original location. Acetonitrile, 2,2dibromo 3252435 acetonitrile 75058 95 4. This colourless liquid is the simplest organic nitrile hydrogen cyanide is a simpler nitrile, but the cyanide anion is not classed as organic. Acetonitrile is the most basic and simple organic nitrile. Sheet msds, available from ineos, for information on the chemical.
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